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KMID : 0882419930440010036
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Korean Journal of Medicine
1993 Volume.44 No. 1 p.36 ~ p.41
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Serum Insulin and C-Peptide Levels in Patients with Hypothyroidism
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이화영
김광조/김천중/김병익/전우규/이만호/정을순/이상종
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Abstract
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ackground : studies for the effect of thyroid hormones on secretion of insulin and glucose metabolism have been reported, but those results appear to be controversial.
Methods : we have investigated the levels of serum C-peptide and insulin following the oral
glucose load in 19 patients with hypothyroidism and 14 normal subjects.
Results :
1) the mean fasting level of serum C-peptide in hypothyroidism was somewhat elevated. The
response of serum C-peptide was significantly enhanced 2 hours after oral glucose
tolerance test in hypothyroid patients (5.16±2.31 Vs 2.01±1.05 ng/ml) (p<0.05).
2) serum insulin response was exaggerated after oral glucose tolerance test in
hypothyroidism. (GTT 1 hour : 90.74±33.56 Vs 61.19±22.91 uU/ml, GTT 2 hour:74.23±36.47
Vs 49.30±0.83 uU/ml)(p<0.05)
3) blood glucose response has been significantly augmented in hypothyroid patients after
oral glucose tolerance test. (GTT 1 hour:129.47±40.20 Vs 98.21±9.10 mg/dl)(p<0.05)
4) the ratio of C-peptide to insulin had no significant difference between patients with
hypothyroidism and normal subjects ststistically.
Conclusion : these results suggested that the slowing of C-peptide and insulin degradation due
to hypometabolism in hypothyroidism could be contributed to higher serum levels of the
C-peptide and insulin.
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KEYWORD
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